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AR-P350/450 AR-M350/450
Technical Information Pack
Document Systems Support
49
MATERIAL SAFETY DATA SHEET
Page:3/3
Date Issued : Nov. 30. 2000
Date Revised:
MSDS NO.: F-01011
Carcinogenicity : In 1996 the IARC reevaluated carbon black as a Group 2B carcinogen (possible human carcinogen).
This classification is given to chemicals for which there is inadequate human evidence, but
sufficient animal evidence on which to base an opinion of carcinogenicity. The classification is
based upon the development of lung tumors in rats receiving chronic inhalation exposures to free
carbon black at levels that induce particle overload of the lung. Studies performed in animal
models other than rats did not show any association between carbon black and lung tumors.
Moreover, a two-year cancer bioassay using a typical toner preparation containing carbon black
demonstrated no association between toner exposure and tumor development in rats.
sufficient animal evidence on which to base an opinion of carcinogenicity. The classification is
based upon the development of lung tumors in rats receiving chronic inhalation exposures to free
carbon black at levels that induce particle overload of the lung. Studies performed in animal
models other than rats did not show any association between carbon black and lung tumors.
Moreover, a two-year cancer bioassay using a typical toner preparation containing carbon black
demonstrated no association between toner exposure and tumor development in rats.
Chronic Effect : In a study in rats of chronic inhalation exposure to a typical toner, a mild to moderate degree of lung
fibrosis was observed in 92% of the rats in the high concentration (16mg/m
3
) exposure group, and a
minimal to mild degree of fibrosis was noted in22% of the animals in the middle (4mg/m
3
) exposure
group, but no pulmonary change was reported in the lowest (1mg/m
3
) exposure group, the most
relevant level to potential human exposures.
12.ECOLOGICAL INFORMATION
No data are available.
13.DISPOSAL CONSIDERATION
Waste from residues : Waste material may be dumped or incinerated under conditions which meet all federal, state and
local environmental regulations..
Contaminated Packaging : Waste may be disposed or incinerated under conditions which meet all federal, state and local
environmental regulations.
14.TRANSPORT INFORMATION
UN Classification : None
Land DOT(USA) : None
Sea IMDG : None
Air ICAO-T I: None
Land DOT(USA) : None
Sea IMDG : None
Air ICAO-T I: None
15.REGULATORY INFORMATION
US Information
TSCA(Toxic Substances Control Act):
All chemical substances in this product comply with all applicable rules or order under TSCA.
SARA(Superfund Amendments and Reauthorization Act) Title III
302 Extreme Hazardous Substance: None
311/312 Hazard Classification: None
EU Information
1999/45/EC and 67/548/EEC
Symbol & Indication: Not required
R-Phrase : Not required
76/769/EEC : All chemical substances in this product comply with all applicable rules or order under 76/769/EEC.
TSCA(Toxic Substances Control Act):
All chemical substances in this product comply with all applicable rules or order under TSCA.
SARA(Superfund Amendments and Reauthorization Act) Title III
302 Extreme Hazardous Substance: None
311/312 Hazard Classification: None
EU Information
1999/45/EC and 67/548/EEC
Symbol & Indication: Not required
R-Phrase : Not required
76/769/EEC : All chemical substances in this product comply with all applicable rules or order under 76/769/EEC.
16.OTHER INFORMATION
NFPA Rating(USA) : Health=1 Flammability=1 Reactivity=0
WHMIS Legislation(Canada): This product is not a controlled product.
WHMIS Legislation(Canada): This product is not a controlled product.
References
IARC(1996) : IARC monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 65, Printing
IARC(1996) : IARC monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 65, Printing
Process And Printing Inks, Carbon Black and Some Nitro Compounds, Lyon, pp.149-261
H.Muhle, B.Bellmann, O.Creutzenberg, C.Dasenbrock, H.Ernst, R.Kilpper, J.C.MacKenzie, P.Morrow, U.Mohr,
S.Takenaka, and R.Mermelstein(1991) Pulmonary Response to Toner upon Chronic Inhalation Exposure in Rats.
Fundamental and Applied Toxicology 17, pp.280-299.
Fundamental and Applied Toxicology 17, pp.280-299.
The information on this data sheet represents our current data and best opinion as to the proper use in handling of this product
under normal conditions. However, all materials may present unknown hazards and should be used with caution. Although
certain hazards are described herein, we do not guarantee that these are the only hazards which exist.
certain hazards are described herein, we do not guarantee that these are the only hazards which exist.
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